ONCOLYTIC VIRUS-MEDIATED REVERSAL OF IMPAIRED TUMOR ANTIGEN PRESENTATION

ONCOLYTIC VIRUS-MEDIATED REVERSAL OF IMPAIRED TUMOR ANTIGEN PRESENTATION

Blog Article

Anti-tumor immunity can eliminate existing cancer cells and also maintain a constant sex shop arles surveillance against possible relapse.Such an antigen-specific adaptive response begins when tumor-specific T cells become activated.T cell activation requires two signals on antigen presenting cells (APCs): antigen presentation through MHC molecules and co-stimulation.In the absence of one or both of these signals, T cells remain inactivated or can even become tolerized.

Cancer cells and their associated microenvironment strategically hinder the processing and presentation of tumor antigens and consequently prevent the development of anti-tumor immunity.Many studies, however, demonstrate that interventions that overturn tumor-associated immune evasion mechanisms can establish anti-tumor immune responses of therapeutic potential.One such intervention is oncolytic virus (OV)-based anti-cancer therapy.Here we teal horse blanket discuss how OV-induced immunological events override tumor-associated antigen presentation impairment and promote appropriate T cell:APC interaction.

Detailed understanding of this phenomenon is pivotal for devising the strategies that will enhance the efficacy of OV-based anti-cancer therapy by complementing its inherent oncolytic.